Ethnic Differences in Estrogen Metabolism in Healthy Women
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منابع مشابه
Ethnic differences in estrogen metabolism in healthy women.
The high incidence of breast cancer observed in young African-American women (7) and the apparent aggressiveness of the disease in this ethnic group (2) might be because of biologic differences, such as genetic susceptibility to environmental factors and/or hormonal levels. We have recently shown (3) that a polymorphism in the CYP1 Al gene, which is involved in estrogen metabolism, is significa...
متن کاملBrassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women.
Previous studies suggest that the estrogen metabolite 16alpha-hydroxyestrone acts as a breast tumor promoter. The alternative product of estrogen metabolism, 2-hydroxyestrone, does not exhibit estrogenic properties in breast tissue, and lower values of the ratio 2-hydroxyestrone:16alpha-hydroxyestrone (2:16) in urine may be an endocrine biomarker for greater breast cancer risk. Vegetables of th...
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Ethnic differences in drug metabolism are well documented for a number of drugs. The molecular mechanisms responsible for ethnic differences in drug metabolism have been partly clarified because of the advances in molecular biology in recent years. Gene dosage determines the drug metabolism as demonstrated for S-mephenytoin and diazepam metabolism. Genotype analysis indicates a different freque...
متن کاملEstrogen metabolism in normal and pregnant women.
The pattern of estrogen metabolism in human pregnancy differs materially from that of the nonpregnant woman in that estrogen production is very great and the output of estriol is disproportionately increased with respect to the other metabolites (1). To obtain information about this latter alteration, the fate of estradiol has been studied in both pregnant and nonpregnant women. It was found th...
متن کاملEthnic differences in lipid and lipoprotein metabolism in pregnant women of African and Caucasian origin.
AIMS To investigate differences in serum lipid, lipoprotein and apolipoprotein concentrations in pregnant women of different ethnic origin. METHODS Serum lipid, lipoprotein and apolipoprotein concentrations were measured in 232 women (114 Caucasians, 118 Africans/Afro-Caribbeans), who presented consecutively for screening for gestational diabetes in the third trimester of pregnancy. RESULTS...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1996
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/88.9.617